Israeli AI drug development company Eleven Therapeutics announced today that it has raised $22 million in seed funding including an investment from the Bill & Melinda Gates Foundation, which committed $9 million in funding to the company. Other investors include Kindred Capital, NFX Bio (formerly TechBio), Harel Technology Investments, Entrée Capital, and the Innovate UK Smart Grant.
Eleven’s is striving to harness combinatorial chemistry and AI to transform RNAi drug development into a programmable process. The company’s platform aims to decipher the structure-activity relationship (SAR) of siRNAs. The number of possible molecular compositions is staggeringly high, exceeding the number of grains of sand on earth. The platform solves this challenge by generating functional data about the activity profile of an unprecedented scale of siRNA molecules in parallel. In order to unlock the rules of SAR, the team is developing a robust deep learning framework. Ultimately, this proprietary, patent-protected, massively parallel screening platform will systematically identify the best combination of building blocks for therapeutic candidates.
The Bill & Melinda Gates Foundation investment includes $5 million towards future equity investment supporting the development of a first-of-its-kind platform that designs small interfering RNAs (siRNAs) with ultra-long durability by utilizing high throughput combinatorial chemistry and AI. The additional $4 million by the Gates Foundation was awarded as a non-dilutive grant furthering Eleven’s development of prophylactics against endemic and pandemic-poised respiratory viruses.
“Eleven’s new platform addresses a long-standing challenge in RNAi,” said Dr. Greg Hannon, Director of the Cancer Research UK Cambridge Institute at the University of Cambridge, scientific co-founder of Eleven, and one of the world’s leading pioneers in RNAi. “The potential chemical space for optimizing these molecules is absolutely massive. Eleven’s solution will map this space by generating unprecedented amounts of data, which can then be leveraged by AI.”
The Gates Foundation’s funding will promote wide accessibility of Eleven’s ultimate treatments to people in need in developing countries. The company additionally has a Cooperative Research and Development Agreement (CRADA) with the Vaccine Research Center of the NIAID.
Eleven Therapeutics cofounder and CEO Prof. Yaniv Erlich said, “The future equity investment and grant funding from the Gates Foundation propels our revolutionary efforts of mapping the chemical space of oligonucleotide therapeutics. Our platforms pave the way for the discovery of groundbreaking RNAi therapeutics and prophylactics against some of the most devastating diseases of our time.”
Published by Globes, Israel business news – en.globes.co.il – on August 2 2022.
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